How to treat cervical cancer recurrence after surgery

The main treatments for cervical cancer recurrence after surgery include surgical resection, radiotherapy, chemotherapy, targeted therapy and immunotherapy. The selection of treatment methods needs to be comprehensively considered based on factors such as the location and scope of recurrence, and the patient’s physical condition.

1. Surgical resection

For local recurrence and localized lesions, surgical resection may be considered. The surgical method will be individually designed based on the location and extent of recurrence, and may include cervical resection, total hysterectomy, or pelvic exenteration. Relevant examinations need to be completed before surgery to evaluate the feasibility of surgery. Postoperative patients need close follow-up to monitor changes in condition.

2. Radiotherapy

Radiotherapy has a good effect on postoperative recurrence of cervical cancer, especially for inoperable local recurrence. External radiotherapy or intracavitary brachytherapy can be used. Radiation tolerance needs to be assessed in patients with a history of radiotherapy. Radiotherapy may cause complications such as radiation enteritis and cystitis, and related symptom monitoring and care need to be strengthened.

3. Chemotherapy

For patients with extensive metastasis or multiple recurrences, chemotherapy is the main option. Commonly used drugs include cisplatin injection, paclitaxel injection and carboplatin injection, etc., using single drug or combined drug regimens. Adverse reactions such as nausea, vomiting, and bone marrow suppression may occur during chemotherapy, and corresponding supportive treatment is required. Treatment cycles and regimens need to be adjusted based on efficacy and tolerability.

4. Targeted therapy

The targeted drug bevacizumab injection can be used to treat recurrent cervical cancer. It inhibits tumor angiogenesis by combining with vascular endothelial growth factors. Often used in combination with chemotherapy, it can significantly extend the progression-free survival of patients. Adverse reactions such as hypertension and proteinuria need to be monitored during use. Some patients may consider immune checkpoint inhibitor treatment such as pembrolizumab injection.

5. Immunotherapy

For patients with positive PD-L1 expression, immune checkpoint inhibitor treatment, such as pembrolizumab injection, can be considered. This type of drug can activate the patient's own immune system to recognize and kill tumor cells. Immune-related adverse reactions such as pneumonia, colitis, etc. may occur, which require close monitoring and timely treatment. Before treatment, it is recommended to conduct biomarker testing to screen potential benefit groups.

Patients with cervical cancer recurrence after surgery should maintain a balanced diet and appropriately increase their intake of high-quality protein, such as fish, eggs, soy products, etc., to help improve the body's resistance. Carry out moderate activities according to your physical condition, such as walking, yoga and other aerobic exercises, but avoid excessive fatigue. Maintain a regular schedule and a good attitude, and strictly follow the doctor's instructions for treatment and follow-up. During the treatment of postoperative recurrence, special attention should be paid to observing changes in symptoms such as vaginal bleeding, abnormal discharge, pain, etc. If there are any abnormalities, seek medical treatment in time. It is recommended to conduct regular gynecological examinations, tumor marker tests and imaging reviews every 3-6 months to detect new conditions in a timely manner.