Can cavernous induration be cured?

In most cases, the symptoms of Peyronie's disease with cavernous induration can be improved through standard treatment, but it is difficult to completely cure it. Treatment options mainly include drug therapy, physical therapy, injection therapy, surgical therapy and lifestyle adjustments. Disease progression is related to factors such as fibrous plaque formation, trauma history, genetic factors, metabolic abnormalities, and chronic inflammation.

1. Drug treatment:

Oral drugs such as colchicine and L-carnitine can be tried in the early stage to delay the process of fibrosis. Non-steroidal anti-inflammatory drugs can be used when the pain is obvious. Local injection of collagenase or glucocorticoids can soften plaques and must be performed under the guidance of a professional doctor. Drug treatment needs to be continued for 3-6 months to observe the effect, and about 50% of patients' symptoms are relieved.

2. Physical therapy:

Extracorporeal shock wave therapy can promote microcirculation of fibrous tissue and can reduce curvature 2-3 times a week for 4 consecutive weeks. The negative pressure suction device combined with traction exercises can improve penis extensibility and should be used for 20-30 minutes every day. Physical therapy is suitable for patients with mild to moderate curvature <30 degrees and needs to be continued for more than 3 months.

3. Injection treatment:

Intra-plaque injection of verapamil can inhibit collagen synthesis, once a month for 3-6 consecutive times, and about 60% of patients have reduced curvature. Interferon injections reduce fibrosis by regulating the immune response, but may cause side effects such as fever. Injection therapy needs to be coordinated with ultrasound positioning to ensure precise drug delivery.

4. Surgical treatment:

Athene excision and suturing is suitable for patients with severe deformity and whose condition has been stable for more than 1 year. Postoperative prostheses may be required. Modified plication corrects the curvature by shortening the tunica albuginea on the healthy side. The operation time is short but there is a risk of recurrence. Surgical intervention is recommended only for patients with erectile dysfunction or dyspareunia.

5. Life adjustment:

Smoking cessation can improve endothelial function and slow down plaque progression. Supplementing vitamin E and coenzyme Q10 may reduce oxidative stress damage. Avoid trauma to the penis and use lubricant to reduce friction during intercourse. Moderate aerobic exercise such as swimming and brisk walking can help promote local blood circulation.

It is recommended that patients regularly monitor plaque changes and review penile ultrasound every 3 months during the acute phase. Pay attention to increasing the intake of anti-inflammatory foods such as deep-sea fish and nuts, and reducing high-sugar and high-fat diets. Taking a sitz bath with warm water for 15 minutes a day can relieve pain and avoid compressing the penis during sleep. Psychological counseling is particularly important for alleviating anxiety, and partners participating in treatment together can enhance confidence in recovery. If the erection angle continues to worsen or new induration occurs, you need to see a doctor promptly to evaluate and adjust the treatment plan.